CD8A and Huntington disease: Furthermore, the CD4+/CD8+ ratio significantly increased at T2 compared to baseline in both HD (2.722 ± 2.051 vs 1.885 ± 1.085, p=0.029) and KTRs (2.941 ± 2.017 vs 1.929 ± 0.986, p<0.001).