In this context, well-characterized bi-epitope DeAns,decorated with both AX and BP allergenic determinants [named amoxicilloyl (AXO) and benzylpenicilloyl (BPO)], showed the ability of specific recognition by IgE of patients allergic to both, AX and BP, with potential in the development for universal in vitro detection of BL allergies (23). Here, IGHE is linked to allergic disease.