Since CXCR2 is more sensitive to low ligand concentrations, CXCR2 is believed to play a more important role at recruiting neutrophils to the site of infection (including bacterial infections in the lungs), whereas CXCR1 mediates oxidative burst and granule release to combat the microbes at the site of infection (29). This evidence concerns the gene CXCR2 and bacterial infectious disease.