Compared with the HG group, however, HG plus HPS groups reduced mRNA levels of M1 macrophage-associated pro-inflammatory mediators iNOS, TNF-α, IL-17, MCP-1 and IFN-γ (Figures 8A–E), while the mRNA levels of anti-inflammatory cytokines Arg-1 and IL-10 (Figures 8F, G) were increased in the group with high concentrations of HPS. Here, NOS2 is linked to Hermansky-Pudlak syndrome.