TNF and neoplasm: Afterward, pathway enrichment analysis of the genes differentially expressed in the two different T-cell infiltration groups were performed, which found that immune signaling pathways such as TNF-α/NF-kB pathway and IL2 pathway (Figure 2A), especially the epithelial-to-mesenchymal transition (EMT) pathway, were closely related to tumor-infiltrating T-cell abundance (ITA).