IRF8 and cancer: To further identify the characteristic molecules, we analyzed the 219 genes using the cytoHubba and selected the top 10 genes (PTPRC, CD2, CD69, IRF8, CCR7, CCL5, il2rb, CXCL10, CCR5, TBX21) as new molecular markers of cancer stem-like cells for GIST patients (Figure 5D).