In the process of module analysis and characteristic molecular screening, we selected two characteristic modules and 10 characteristic molecules (PTPRC, CD2, CD69, IRF8, CCR7, CCL5, il2rb, CXCL10, CCR5, TBX21), which could be used as biomarkers of cancer stem-like cells for GIST patients. The gene discussed is TBX21; the disease is gastrointestinal stromal tumor.