The results highlighted the close associations among the inflammatory response (including cytokines CRP and PCT-M), the dysfunction of tissues (such as liver and kidney), the coagulation index [such as APTT (R), INR, and PT (S)], and the dynamic changes of metabolic profiles (especially for amino acids, peptides, and analogs) in the COVID-19 progression, especially for severe patients. The gene discussed is CRP; the disease is COVID-19.