A significant positive correlation was reported between GHD and pituitary fibrosis, that the cross-talk between craniopharyngioma cells and pericytes in the pituitary plays a critical function in forming GHD, and that interleukin (IL)-1α activates pericytes through IL-1R1-related signaling pathway and then causes pituitary fibrosis, finally leading to decreased GHD levels in craniopharyngioma (40). This evidence concerns the gene IL1R1 and craniopharyngioma.