GH1 and mucopolysaccharidosis type 3D: The largest long-term study of children receiving chemotherapy and radiotherapy (748 participants with an average follow-up period of 27.3 years) revealed that cumulative incidence of growth hormone (GH), thyroid-stimulating hormone (TSH), adrenocorticotrophic hormone (ACTH), and gonadotropin (Gn) deficiency at the age of 40 was 72.4, 11.6, 5.2, and 24.4%, respectively (33).