In the models of intracerebral hemorrhage (ICH), Batroxobin effectively attenuated brain edema formation and decreased bleeding, possibly by decreasing the concentration of malondialdehyde (MDA) and free Ca2+, increasing the SOD activities and down-regulating the expression of Intercellular Adhesion Molecule 1 (ICAM-1) and complements, such as C3d and C9 (15, 65). Here, SOD1 is linked to intracerebral hemorrhage.