TG and Down syndrome: - Lithium, thyroid hormone replacement, amiodarone, beta adrenergic agonists, antiepileptics (valproate, carbamazepine, phenytoin), SSRI and imipraminic antidepressants, typical antipsychotics and antiemetics, immunosuppressants (cyclosporine, tacrolimus), anti-neoplastic agents - Withdrawal syndromes to benzodiazepines, ethanol, opiates