SLC8A1 and ischemia: Thus, ongoing pharmacological interventional studies are now focused on the selective ion channels [e.g., atrial I(Na), I(Kur) and I(K, ACh)], pathology-selective ion channels [constitutively active I(K, ACh), TRP channels], ischemia-uncoupled gap junctions, proteins related to malfunctioning intracellular Ca(2+) homeostasis [e.g., “leaky” ryanodine receptors, overactive Na(+), Ca(2+) exchanger] or risk factors for arrhythmias (“upstream” therapies) (Ravens, 2010).