Specifically, there is strong support in the literature about the influence of maternal body mass index or gestational weight gain on the development of diseases or certain phenotypes, such as preterm delivery risk, risk of obesity at any age, and expression of energy sensing genes in the placenta, such as mTOR downstream genes (Schack-Nielsen et al., 2005; Oken et al., 2008; Martino et al., 2016; Oskovi Kaplan and Ozgu-Erdinc, 2018). The gene discussed is MTOR; the disease is obesity due to melanocortin 4 receptor deficiency.