ACLY and autoimmune polyendocrinopathy: APS is an autoimmune disease characterized by clinical manifestations of thrombosis or pregnancy morbidity and persistent antiphospholipid antibodies (aPL), including lupus anticoagulant (LA), anti-cardiolipin antibodies (aCL), and anti-β2-glycoprotein-I (aβ2GPI; Miyakis et al., 2006).