Contrarily, patients with obstetric APS who have pregnancy morbidity plus thrombosis and high aPL titers, particularly those with triple aPL positivity, have an ineffective standard of care, but the addition of hydroxychloroquine (HCQ) improves the gestational outcome (De Carolis et al., 2017; Ruffatti et al., 2017; Mekinian et al., 2018). Here, FASLG is linked to autoimmune polyendocrinopathy.