Hence, the role of aCL in this event was unclear, but Simoncini et al. (2005) showed that after eliminating aβ2GPI, aPL from patients with APS-induced ROS production in endothelial cells compared with the NHS IgG control, suggesting the relevance of β2GPI-independent aCL. Here, ACLY is linked to autoimmune polyendocrinopathy.