Several studies have demonstrated that pyroptosis might have a role in cataract formation and that the levels of pyroptosis markers, such as NLRP3, pro-caspase-1, active caspase-1, GSDMD-N, IL-1β, and IL-18, are significantly increased in the capsule tissues or cells of cataract patients (Sun et al., 2020). This evidence concerns the gene CASP1 and cataract.