These studies illustrated the existence of Aβ-induced AMD models with secretion of mature proinflammatory cytokines, including inflammatory factors (IL-18 and IL-1β), and evidence supporting GSDMD-mediated activation of the pyroptosis pathway in RPE cells, suggesting the importance of pyroptosis in AMD pathogenesis, while inhibiting the target of the pyroptosis pathway may benefit the prognosis of AMD. Here, IL18 is linked to age-related macular degeneration.