In fungal keratitis, pretreatment with thymic stromal lymphopoietin (TSLP), a kind of inflammatory factor similar to IL-7 that is mainly produced by epithelial cells, promoted the expression of NLRP3, ASC, caspase-1, GSDMD, IL-1β, and IL-18 in THP-1 macrophages, which was abolished by NLRP3 knockdown. The gene discussed is CASP1; the disease is fungal keratitis.