With prolonged inflammation of the retina, RPE cells became enlarged or swollen and exhibited a significant increase in proteolysis of full-length GSDMD in RPE choroidal tissue, and the expression of GSDMD-N, caspase-1, IL-1β, and IL-18 was also significantly increased in intravitreal Aβ-induced AMD models (Gao et al., 2018; Sun et al., 2018). This evidence concerns the gene CASP1 and age-related macular degeneration.