TGFB1 and Myocardial fibrosis: Abundant evidence has indicated that the conduction of ERK/MAPK signaling pathway is closely related to myocardial fibrosis and hypertrophy (Sun et al., 2018), whereas TGF-β signaling pathway plays a key role in the occurrence and development of cardiac fibrosis (Yu et al., 2002; Leask, 2007).