However, SCN1A gene variants are also a recognized cause for epilepsies and neurodevelopmental disorders outside the Dravet syndrome spectrum—ranging from milder phenotypes such as generalized epilepsy with febrile seizures plus (Escayg et al., 2000), to other epilepsy syndromes such as myoclonic astatic epilepsy, epilepsy of infancy with migrating focal seizures, or even to recently described more severe early onset epileptic encephalopathies with neurodegeneration and dyskinesia (Sadleir et al., 2017; Beck et al., 2019; Gorman et al., 2021). Here, SCN1A is linked to encephalopathy, progressive, early-onset, with brain edema and/or leukoencephalopathy.