Other well-characterized focal epilepsies with single gene causes include familial focal epilepsy with variable foci caused by DEPDC5 variants (Dibbens et al., 2013), childhood epilepsy with centro-temporal spikes caused by GRIN2A variants (Lemke et al., 2013), and autosomal dominant nocturnal frontal lobe epilepsy (ADNFLE) associated with CHRNA4, CHRNB2, CHRNA2, KCNT1, DEPDC5, or CRH (Kurahashi and Hirose, 2002). Here, CHRNA4 is linked to autosomal dominant nocturnal frontal lobe epilepsy.