Hepatocellular carcinoma (HCC) is one of the most common malignant tumors, and Yu et al. conducted a systematic transcriptome study on HCC, determining that the methylation level of zinc finger and SCAN domain-containing 18 (ZSCAN18) can be used as an indicator for HCC prognosis and that ABHD6 is a potential tumor suppressor (Yu et al., 2016). This evidence concerns the gene ZSCAN18 and hepatocellular carcinoma.