SCN10A and neuropathy, small fiber: Nowadays, about 800 variants have been described in the SCN10A gene encoding the NAV1.8 channel in the ClinVar NCBI database (https://www.ncbi.nlm.nih.gov/clinvar queried the August 26, 2021), and potentially pathogenic variants of the SCN10A gene were found in 3.7% of patients with small fiber neuropathy (SFN) (Eijkenboom et al., 2019).