EGFR and hepatocellular carcinoma: In the study, we demonstrated that cinobufagin exhibited specific antiproliferation effect in the special carcinoma cells with EGFR expression, including glioblastoma cells, lung cancer cells, colorectal cells, and hepatocellular carcinoma cells (Figures 1A, 3A,C, 4B,C, Supplementary Figure S4A,B).