Remarkably, cases of interferon-induced PAH suggest a causal link between interferon (IFN) exposure and PAH (Al-Zahrani et al., 2003; Jochmann et al., 2005; Ledinek et al., 2009; Dhillon et al., 2010; Savale et al., 2014); subsequently, basic experiments validated the interaction between IFN and PH (Badiger et al., 2012; George et al., 2014). Here, IFNA1 is linked to pulmonary arterial hypertension.