↓ VEGF-induced vascular endothelial cell proliferation, invasion and tube formation; VEGFR2 activation, MMP-2/9 and VEGF expression ↑ G2/M phase arrest, NADPH oxidase activity, reactive oxygen species, cleaved caspase-3 and cleaved PARP ↓ tumor growth in a nude mouse. The gene discussed is FMO5; the disease is neoplasm.