CASP1 and inflammatory bowel disease: The myotubularin-related protein 3 (MTMR3) reduced the level of autophagy induced by pattern recognition receptor (PRR) while increasing PRR-induced CASP1 activation, IL-1β secretion, the activation of the NFκB signaling, and finally increased the secretion of overall cytokines in IBD (Lahiri, et al., 2015).