The main neuropathological hallmarks of AD include the accumulation of amyloid beta peptide (Aβ)-containing plaques, hyperphosphorylated tau protein (p-tau)-composed neurofibrillary tangles, extensive neuroinflammation, synaptic loss, and neuronal cell death (Serrano-Pozoe et al., 2011). Here, MAPT is linked to Alzheimer disease.