APOE and Onset: Interestingly, the two greatest genetic risk factors for late-onset AD (LOAD), apolipoprotein E (apoE) and bridging integrator-1(Bin1), are involved in EV biogenesis and/or cargo sorting (Crotti, et al., 2019; Peng, et al., 2019), suggesting direct involvement of EVs in the development AD pathophysiology.