IL6 and kidney disorder: When exposed to inflammatory stimulant, free NF-κB translocates from the cytoplasm to the nucleus, and phosphorylated subunit p65 stimulates transcription of pro-inflammatory cytokine IL-1β, IL-6, and TNF-α, which promote their secretion and triggering an increased inflammatory response (Peerapornratana et al., 2019), and thus play a key role in the pathogenesis of kidney disease (Liu et al., 2018).