IGHE and Alzheimer disease: AD involves an aberrant immune response involving several crosslinks, including antigen recognition, processing, and presentation in Langerhans cells (LCs) and dendritic cells (DCs); Th2-dominant abnormal immune responses; compromised function of regulatory T cells; IgE overexpression; and increased eosinophil levels (Guttman-Yassky et al., 2017; Peng and Novak, 2015).