In addition to regulating tumor microenvironment-related factors, such as interleukins, interferons, tumor necrosis factors, chemokines, and growth factors, TCM treatments can also regulate immune cells by restoring the antigen expression function of dendritic cells, enhancement of natural killer cell activity, and inhibition of associated fibroblasts (Takei et al., 2004; Mu et al., 2016; Wang et al., 2020). Here, TNF is linked to neoplasm.