Matrix metalloprotein (MMP13) by degrading extracellular matrix (ECM) stimulates the release of VEGF from ECM and thereby promoting angiogenesis and metastasis in skin squamous cell carcinoma and colitis induced colon cancer (Lederle et al., 2010; Ai et al., 2015). The gene discussed is VEGFA; the disease is malignant colon neoplasm.