Inhibition of this neuronal activity can lead to a reduction in gamma oscillations, and the reduction of gamma oscillations in the brain of APOE4 carriers (Traub et al., 2003; Colgin et al., 2009; Buzsaki and Wang, 2012; Gillespie et al., 2016) is closely related to the symptoms of AD (Zhao et al., 2018; Etter et al., 2019; Najm et al., 2019). Here, APOE is linked to Alzheimer disease.