Down-regulated AADGs are enriched for synapses (including cell junction, cholinergic/GABAergic/dopaminergic/glutamatergic synapse, AMPA etc.)and ion/transport (Figure 3 and Supplementary Table 6); The comparison suggests that different from the normal aging process, the AD-specific and aging/AD commonly affected genes are more enriched for glycoprotein, inflammatory response, synapse and mitochondrial dysfunction, while the aging process are more related to the nucleus, acetylation, coiled coil, which are less directly related to neurodegenerative phenotype. This evidence concerns the gene ART4 and Alzheimer disease.