Guam ALS/PDC neurons with tau inclusions also contained mitotic markers (Husseman et al., 2000); such changes result from disruption of neuronal development, as seen in rodents treated with cycasin or MAM (Ferguson, 1996; Chevassus-au-Louis et al., 1999; Schwartzkroin and Wenzel, 2012; Kisby et al., 2013; Luhmann, 2016). The gene discussed is MAPT; the disease is amyotrophic lateral sclerosis.