Thus, PGRN levels do reflect the PGRN metabolism as it has been shown for patients with frontotemporal dementia with and without GRN mutations (Körtvélyessy et al., 2015; Wilke et al., 2017; Goossens et al., 2018; Körtvelyessy et al., 2018). The gene discussed is GRN; the disease is frontotemporal dementia.