In our study, we observed a positive correlation between TP53 and PDL1 mRNA expression, suggesting that there is a synergistic effect between PDL1 and TP53 in the occurrence and development of tumors, which has also been demonstrated in NSCLC wherein TP53 has been shown to regulate PDL1 expression via miR-34 that binds PDL1 3′-untranslated region in NSCLC models [62, 63]. This evidence concerns the gene CD274 and non-small cell lung carcinoma.