CD274 and neoplasm: It has been suggested that CD8+ T cells upregulate PD1 expression and secrete IFN-γ when they encounter tumor antigens, resulting in the upregulation of PDL1 expression on tumor cells and immune cells and the ligation of PDL1 with PD1 will decrease T cell function and create a negative feedback mechanism that decreases antitumor immunity leading to tumorigenesis [22].