The affinity of COVID-19 to the ACE2 receptors expressed abundantly on vascular endothelium, leads to both direct local as well as systemic immune response to pathogen (“cytokine storm”) leading to a widespread thrombosis, microangiopathy and angiogenesis, which disrupts the ACE2 mediated regulation of sympathoadrenal system, vascular autoregulation and cerebral blood flow [8, 14]. This evidence concerns the gene ACE2 and COVID-19.