Multiple mutated driver genes have been identified and are enriched in various signal pathways that are pivotal contributors to melanoma carcinogenesis and development, including mitogen-activated protein kinase (MAPK) pathway, protein kinase B (AKT) pathway, cell-cycle regulation pathway, pigmentation-related pathway, p53 pathway, epigenetic factors, and some other pathways. Here, AKT1 is linked to melanoma.