The inhibition of DBT contributes to BCAAs accumulation and attenuates oncogene-induced apoptosis of melanocytes, suggesting that DBT is a gatekeeper mediating mutant BRAF-driven malignant transformation from melanocytes to melanoma.255 What’s more important, melanoma cells harboring BRAF mutation and hyper-activation of the MAPK pathway are highly dependent on leucine for survival. The gene discussed is BRAF; the disease is melanoma.