T cells and NK cells express several cell surface co-stimulatory receptors which belong to TNFR family that induce the effector function of T cells and NK cells in tumor environment.648 Members of TNFR family including CD137, OX40, GITR, CD40, and CD27 have long been considered as viable immunotherapy targets. The gene discussed is TNFRSF1A; the disease is neoplasm.