Meanwhile, the upregulation of ERBB3 after BRAF inhibitor treatment is highly attributed to FOXD3-mediated transcriptional activation.421 What’s more, canonical melanocytic lineage-specific transcriptional factor MITF is also reported to be induced and to promote downstream PGC1α-dependent oxidative phosphorylation.200,422 Therefore, the suppression of MITF and mitochondrial function could be promising in overcoming adaptive resistance of melanoma cells to targeted therapy. The gene discussed is FOXD3; the disease is melanoma.