Specific inhibition of highly-expressed H3K9-active demethylases restores oncogene-induced senescence and suppresses melanoma development.170 In addition, the ablation of LSD1 enhances tumor immunogenicity via the upregulation of endogenous retroviral element (ERV) transcripts and the downregulation of RNA-induced silencing complex. The gene discussed is KDM1A; the disease is melanoma.