Supplementary to histone acetylation, histone methylation also impacts chromatin condensation and gene transcription to regulate melanoma biology,145 with some enzyme families like SET domain bifurcated 1 (SETDB1), disruptor of telomeric silencing 1-like proteins (Dot1L), enhancer of Zeste homolog 2 (EZH2) and LSD1 implicated in. The gene discussed is DOT1L; the disease is melanoma.