The inflammatory signal pathway is highly related to tumor carcinogenesis and progression, with no exception in melanoma.333 Inflammatory factors including tumor necrosis factor (TNFα), IFN-γ, interleukins, and related regulatory signalings such as Janus kinase (JAK)-STAT, NF-κB, and inflammasome have attracted more and more attention in the investigation of melanoma biology and tumor microenvironment. The gene discussed is TNF; the disease is neoplasm.