Loss of METTL3 in myeloid cells can prominently impair YTH N6-methyladenosine RNA binding protein-1 (YTHDF1)-mediated translation of sprouty related EVH1 domain-containing 2 (SPRED2), which promotes the activation of nuclear factor kappa B (NF-kB) and STAT3 through ERK pathway, leading to increased tumor growth and metastasis. This evidence concerns the gene SPRED2 and neoplasm.