TGFB1 and melanoma: In tumor microenvironment, mesenchymal stem cell-derived TGF-β promotes melanoma cell EMT in paracrine/autocrine-dependent manner.280 What should be noted is that TGF-β-mediated transcriptional profile also facilitates ameboid phenotype independent of the EMT process to promote melanoma cell dissemination.281 Downstream the above-mentioned oncogenic pathways, EMT-TFs are indeed master regulator of melanoma phenotype switching in a transcriptional regulation-dependent manner.