Genetic knockdown of BCAT1 expression impairs the proliferative capacity of melanoma cells via the suppression of mitochondrial oxidative phosphorylation.254 Moreover, genome-wide CRISPR/Cas9 knockout screening assay has identified that dihydrolipoamide branched-chain transacylase (DBT), a subunit of BCKDH, is implicated in the regulation of cell apoptosis induced by BRAFV600E overexpression in melanocytes. The gene discussed is DBT; the disease is melanoma.