With the use of proteomics, metabolomics, and multiple brain metastasis models, it has been revealed that the metastatic lesions of melanoma is sensitive to the limitation of serine synthesis in nutrient-limited environment, making PHGDH an attractive target to control melanoma distant metastasis.243 Recent study regarding targeted therapy forwardly shows that PHGDH upregulation also renders the resistance to MEK inhibitor in melanoma harboring NRAS mutation. This evidence concerns the gene MAP2K7 and melanoma.