To be specific, homing of melanoma cells-derived exosomes to sentinel lymph nodes exerts integrated effects on melanoma cell recruitment, extracellular matrix deposition, and vascular proliferation in the lymph nodes, thus helping microanatomic niche preparation to facilitate tumor cell lymphatic metastasis.319 Later, it was unveiled that exosomes from highly metastatic melanoma could educate bone marrow progenitor cells toward a pro-vasculogenic phenotype and trigger vascular leakiness at pre-metastatic sites through the receptor tyrosine kinase MET. This evidence concerns the gene MET and melanoma.