SNAI1 and cancer: The snail family member snail1 was reported to induce EMT by directly repressing the transcription of E-cadherin.386 Glycogen synthase kinase 3β (GSK3β) and protein kinase CK1 are responsible for binding and phosphorylating Snail to regulate beta-Trcp-mediated ubiquitination and subcellular localization.387,388 Cancer cells have to break down cell–cell and cell–matrix attachment in EMT, which involves cadherin switch, intrinsic and extrinsic signals, as well as a dramatic reorganization of the cytoskeleton.