Over the past few years, HDAC inhibitors have been discovered and reviewed both as single anticancer agents and in combination with other chemotherapeutic drugs/radiotherapy.521–531 For example, the histone deacetylase inhibitor suberoylanilide hydroxamic acid (SAHA; vorinostat (Zolinza)) may cause cell death in tumor cells and tumor-bearing animals. This evidence concerns the gene HDAC9 and neoplasm.