In the studies of colon cancer and hepatocellular carcinoma (HCC), MDM2-mediated HuR neddylation at sites K313 and K326 promoted its nuclear localization, avoiding cytoplasmic ubiquitination and degradation.264,265 The higher expression level of neddylation enzymes NAE1 and UBA3 in glioblastoma with poor clinical outcomes indicated neddylation can be considered as a therapeutic target. This evidence concerns the gene UBA3 and hepatocellular carcinoma.