Cell migration and invasion were suppressed after lentiviral-mediated OGT silencing and increased in OGA-specific inhibitors NButGT and PUGNAc treatment.277 In the study of lung and colon cancer, not only O-GlcNAcylation and global O-GlcNAc transferase expression but also the OGT mRNA levels were evaluated in tumor tissues.278 Similarly, a high level of O-GlcNAcylation in target proteins was detected and was associated with the pathogenesis of characterizes chronic lymphocytic leukemia.279 O-GlcNAcylation targets are involved in various biological processes and signal cascades. This evidence concerns the gene OGT and B-cell chronic lymphocytic leukemia.