The novel ceramidase inhibitors (1 S,2 R)-N-myristoylamino-phenylpropanol-1 (d–e-MAPP) and (1 R,2 R)-N-myristoylamino-4′-nitro-phenylpropandiol-1,3 (B13) was synthesized and examined to block Src N-myristoylation.582 As with NMT1 knockdown, a small-molecule inhibitor B13 blocked NMT1 enzymatic activity and suppressed proliferation, migration, and invasion in vitro and tumor growth in vivo.260 Tris (dibenzylideneacetone) dipalladium (Tris DBA), an organopalladium compound identified in the melanoma study, showed NMT1 inhibition function. This evidence concerns the gene NMT1 and melanoma.