Glutamine is catalyzed by glutaminase GLS to transform into glutamate, and glutamate dehydrogenase convers glutamate intoαKG to enter TCA cycle.114 In some types of cancers like human pancreatic ductal adenocarcinoma (PDAC), glutamate and oxaloacetate (OAA) are transformed into αKG and aspartate. Here, GLS is linked to cancer.