TP53 and neoplasm: The inhibition of tumor growth and failure of glioma self-renewal were found in ACSS2 deficient mice.42,43 A large number of nonhistone proteins can also be modified by crotonylation in the regulation of subcellular location, cellular composition and function, signal pathways, and biological processes.44 After crotonic acid treatment, serine 46 residue in p53 was identified to be crotonylated other than other protein family members p63 and p73.