The S100 protein family show widely functions in every stage of cancer development by regulating key signal pathways.366 One of the membrane-located S100A10 was reported highly expressed in ovarian cancer, breast cancer, colorectal cancer, renal cell carcinoma, and gastric cancer.367–371 The high level of succinylation of S100A10 at K47 was found in gastric cancer and metastatic lymph node tissue to inhibited ubiquitination-related proteasome degradation. This evidence concerns the gene S100A10 and hereditary clear cell renal cell carcinoma.