Also, HBeAg positive (HR 0.158, 95% CI: 0.040–0.634; P = 0.009), cART (HR 0.016, 95% CI: 0.009–0.136; P < 0.001) and CD4 > 200/ul (HR 0.336, 95% CI: 0.144–0.786; P = 0.012) were protective factors to against liver fibrosis in individuals with HIV/HBV co-infection. This evidence concerns the gene CD4 and Hepatic fibrosis.