CLK2 and hepatocellular carcinoma: Among the deregulated genes after treatment with exogenous antioxidants, Transmembrane BAX Inhibitor Motif Containing 1 (TMBIM1) and CDC Like Kinase 2 (CLK2) mRNA were significant upregulated upon NAC and GSH treatments (Fig. 6a, b) and these 2 genes were also significantly overexpressed in both TCGA database and our in-house RNA-seq database on 41 pairs of clinical HCC patients (Fig. 6c and Additional file 1: Fig. S6a).