CD27 was the only common CTSF-related immunostimulator associated with prognosis of LUAD and LUSC, although its role in LUAD and LUSC was distinctively different, demonstrating that though LUAD and LUSC belong to NSCLC, CTSF-related immunomodulators in the two subtypes of NSCLC are quite different. This evidence concerns the gene CD27 and non-small cell lung carcinoma.