DAPK1 and adenoma: In the thyroid tissue and blood of nodular goitres, adenoma, and PTC, the degree of DNA methylation of phosphatase and tensin homologue (PTEN) and death-related protein kinase (DAPK) are negatively correlated with the transcription level, indicating that the high methylation of CpG islands in these gene initiator regions inhibits transcription, The PETN and DAPK methylation statuses combined with BRAFV600E mutation improves the diagnostic performance [66].