Pleckstrin homology domain containing, family S member 1(PLEKHS1) initiator methylation is less common in PTCs and ATCs, and the high expression of PLEKHS1 is associated with PTC lymph nodes and distant metastasis but shortens OS and DFS in PTC patients. The gene discussed is PLEKHS1; the disease is Ehlers-Danlos syndrome, musculocontractural type.