In this study, insulin resistance was highly and significantly correlated with both chemerin and omentin, so it can be inferred that the regulation of chemerin and omentin expression by PEX-168 may be related to the hypoglycaemic effect of PEX-168, and the weight-reducing effect of PEX-168 is unlikely to be the reason for the changes in both. The gene discussed is RARRES2; the disease is Insulin resistance.