Therefore, GSEA was also conducted to explore how EIF3A participates in ccRCC pathogenesis, and the results revealed that the pathways with strong correlations included renal cell carcinoma, endometrial cancer, adherens junctions, rab guanyl nucleotide exchange factor activity, response to hepatocyte growth factor, and response to hepatocyte growth factor. Here, AGFG1 is linked to hereditary clear cell renal cell carcinoma.