STMN2 and diabetes mellitus: An altered balance between glucagon and Stmn2 has also been reported in islets from patients with diabetes; α-cell RNA sequencing analysis showed a higher Gcg: Stmn2 gene expression ratio in islets from people with type 2 diabetes compared to healthy subjects.36 Proglucagon gene transcription, glucagon synthesis and secretion are all highly responsive to prevailing glucose concentrations,16,37–39 reflecting the hyperglucagonemic state of diabetes.