In contrast, insulin showed a strong colocalization with Rab11A (PCC 0.63 ± 0.09) or Rab11B (PCC 0.61 ± 0.06), which significantly decreased (p < .001) following induction of diabetes (colocalization of insulin with Rab11A, PCC 0.35 ± 0.5, or Rab11B, PCC 0.38 ± 0.07). The gene discussed is INS; the disease is diabetes mellitus.