For example, upregulation of ICT1 in hepatocellular carcinoma (HCC), the most aggressive and lethal liver tumour, promotes cell proliferation and cell cycle progression as well as inhibiting apoptosis of tumour cells by regulating the expression of proteins involved in the cell cycle and apoptosis, such as CDK1, cyclin B1, Bcl-2 and Bax. Here, BCL2 is linked to hepatocellular carcinoma.