KDR and cancer: It is worth stressing that plenty of quinoline derivatives provoked their anticancer impact through different mechanisms of action, such as inhibition of DNA repair, tubulin polymerisation, and inhibition of various enzymes implicated in critical cancer cell proliferation prominently kinases enzymes (EGFR, VEGFR, pim-1 kinase, c-Met factor, and PI3K) which stood out as one of the most significant targets implemented in cancer therapy due to their functions in cellular signal transduction.26–30