Our study only addresses part of the effects of Sidt2 on kidney structure and function, but what is interesting is that the accumulation of key autophagy proteins and the impairment of kidney structure and function caused by Sidt2 deletion are similar to the changes in key autophagy proteins and significantly increased proteinuria seen in diabetic nephropathy [37, 47]. This evidence concerns the gene SIDT2 and diabetic kidney disease.