Expression of HES4 (hes family bHLH transcription factor 4) has been implicated in poor outcomes for patients with Triple Negative Breast Cancer (TNBC) (Stoeck et al., 2014) and both HES4 and C1orf159 (chromosome 1 open reading frame 159) have been implicated via functional annotation (nearest gene) of other genome-wide significant loci for several traits and diseases, including peak expiratory flow (PEF) (Ghoussaini et al., 2021, Neale Lab, 2021). The gene discussed is HES4; the disease is triple-negative breast carcinoma.