FRAS1 and Fraser syndrome: Additionally, gene FRAS1 identified by eQTL associations for SNPs in the rs111552599 suggestive signal credible set has been implicated by other genome-wide signals for lung function, specifically for trait FEV1/FVC (Kichaev et al., 2019, Shrine, 2019) and mutations in FRAS1 have been observed amongst individuals with Fraser syndrome, which can cause airway abnormalities (Pitera et al., 2008, van Haelst et al., 2007).