They can be initiated at a eGFR as low as 20 mL/min/1.73 m2 and may be continued until dialysis (they are contraindicated in dialysis).173,174 An initial decrease in eGFR is expected with an SGLT2 inhibitor and per guidelines the agent should not be discontinued unless serious acute kidney injury is suspected.175 SGLT2 inhibitors are not approved for T1D. The gene discussed is SLC5A2; the disease is type 1 diabetes mellitus.