In T2D, insulin (usually as basal insulin) should be started when glucose cannot be controlled with other agents, and the insulin regimen should be intensified as the disease progresses (see detailed reviews of insulin therapy in T2D).5,129 CGM (or structured SMBG for patients without access to CGM) is essential for patients on insulin therapy to ensure optimal dosing and safety. The gene discussed is INS; the disease is type 2 diabetes mellitus.