NPPB and heart failure: Heart Failure), both natriuretic peptides (N-terminal [NT]-pro-B-type natriuretic peptide [NT-proBNP] or BNP) and high-sensitivity troponin T or I (hs-TnT or hs-TnI) are useful biomarkers of the presence and severity of HF.64,65 Natriuretic peptides may be particularly useful in the differential diagnosis of HF when the cause of dyspnea is unclear.65 Elevated troponin indicates myocyte injury or necrosis in patients with myocardial injury or diagnosed HF.64,65