Besides STAT3/c-Myc signaling pathway, various signaling pathways, including RANKL (receptor activator of nuclear factor-κB ligand)/ RANK (receptor activator of nuclear factor-κB) and Wnt signalings, were also involved in the tumorigenesis of osteosarcoma [25, 26]. The gene discussed is TNFSF11; the disease is osteosarcoma.