SMAD3 and liver cancer: In addition, diosmetin inhibited the activity of cytochrome P450 enzymes, regulated the TGF-β signal pathway by up-regulating the expression of p53 and down-regulating the protein expression of Bcl-2, TGF-β, TβR-II, Smad-3, p-Smad2/3, and induce HepG2 apoptosis in liver cancer [43].