Modulation of WNT signaling and other signaling pathways such as mTORC1, STAT3, NF-kB, and Notch pathways, by niclosamide impairs the ability of CML LSCs to survive and self-renew by disrupting [200]. The gene discussed is NFKB1; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.