IL-1RAP, as an interleukin 1 receptor-1 (IL1R1) coreceptor, leads to increased proliferation of CML LSCs by binding of IL-1A or IL-1B and activation of the NF-κB, JNK, and P38-MAPK signaling pathways [33]. The gene discussed is IL1RAP; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.