AKT1 and chronic myelogenous leukemia, BCR-ABL1 positive: Moreover, inhibition of the PI3K/AKT signaling pathway by antagomiR-21 along with IM amplifies programmed cell death 4 (PDCD4) and PTEN, while decreases AKT phosphorylation and MYC expression, which recovers sensitivity of CML LSCs to TKIs by miR-21 depletion [145, 188].