Four representative cases with similar densities of CD8 (3.5–8.6%) and CD20 (3.3–8.2%) are shown in Fig. 6B. The localization maps indicate that the lymphocytes in spots 035 and 097 have more spatially scattered, tumor-infiltrating patterns, whereas in spots 012 and 060 lymphocytes tended to be arranged in close proximity, particularly for the CD20 B-lymphocytes. Here, CD8A is linked to neoplasm.