Finally, UNC5C, UNC5D, and SEPT9 were observed with similar methylation patterns in CRC, which suggests that elevated methylation of UNC5C and UNC5D may have the same clinical applications as SEPT9. As is known that the methylated SEPT9 (mSEPT9) assay was the first blood-based methylation test approved by the United States Food and Drug Administration for colorectal screening. This evidence concerns the gene UNC5D and colorectal carcinoma.